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Cat. No. Product Name Target Signaling Pathways
T4469 Nemorubicin

Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星

Others Others
Nemorubicin (PNU 152243) 是一种 Doxorubicin 衍生物,具有抗肿瘤活性。它需要完整的核苷酸切除修复系统才能发挥活性。它对多药耐药表型的多种肿瘤细胞系具有细胞毒性。
T71467 Nemorubicin HCL

Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway...
T71465 IDP-73152

IDP-73152 is a peptide deformylase inhibitor.
T16557 PNU-159682

Topoisomerase DNA Damage/DNA Repair
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。
T18302 Mal-Phe-C4-VC-PAB-DMEA-PNU-159682

Others Others
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 encompasses metabolites of nemorubicin (MMDX) derived from liver microsomes, as well as the ADC cytotoxin PNU-159682[1].
T17802 DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Others Others
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1].
T18292 Mal-PEG4-VC-PAB-DMEA-PNU-159682

Others Others
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, DMEA-PNU-159682, is derived from metabolites of nemorubicin (MMDX) found in liver microsomes, as well as the ADC cytotoxin PNU-159682[1].

化合物

Nemorubicin
Cat.No: T4469
Synonym: Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星
Target: Others
Nemorubicin HCL
Cat.No: T71467
Synonym:
Target:
IDP-73152
Cat.No: T71465
Synonym:
Target:
PNU-159682
Cat.No: T16557
Synonym:
Target: Topoisomerase
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
Cat.No: T18302
Synonym:
Target: Others
DBCO-PEG4-VC-PAB-DMEA-PNU-159682
Cat.No: T17802
Synonym:
Target: Others
Mal-PEG4-VC-PAB-DMEA-PNU-159682
Cat.No: T18292
Synonym:
Target: Others
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