Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9350 |
IMP-1088
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
IMP-1088 是一种人N-肉豆蔻酰基转移酶NMT1和NMT2双重抑制剂,对 HsNMT1 和 HsNMT2 的IC50小于1 nM,对 HsNMT1 的Kd 小于210 pM。它有保护宿主细胞免受病毒感染的细胞毒作用,通过阻断鼻病毒的 N-肉豆蔻酰化蛋白来阻断鼻病毒的复制。 | |||
T63788 |
PCLX-001
|
Others | Others |
PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2]. |