Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39476 |
NLG802
|
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
NLG802 是 indoximod 的前药,indoximod 是一种口服活性的吲哚胺2,3-双加氧酶(IDO)抑制剂。 | |||
T69944 |
NLG802 HCl
|
||
NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res... |