Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11972 | Mcl-1 inhibitor 3 | BCL | Apoptosis |
Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). | |||
T11970 |
MCL-1/BCL-2-IN-3
|
Others | Others |
MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely. | |||
T62941 | Bcl-2/Mcl-1-IN-3 | ||
Bcl-2/Mcl-1-IN-3 是一种 Bcl-2/Mcl-1 抑制剂,作用于 Mcl-1 (Ki: 0.14 μM) 和 Bcl-2 (Ki: 0.23 μM),能够用于研究癌症。 | |||
T21786 |
Apogossypolone (ApoG2)
|
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Apogossypolone (ApoG2) 是一种具有口服活性的Bcl-2 家族蛋白抑制剂,对 Bcl-2, Mcl-1 和 Bcl-XL 的Ki 值分别为 35, 25 和 660 nM。Apogossypolone 具有抗肿瘤活性,可诱导细胞凋亡 (apoptosis) 和 自噬 (autophagy)。Apogossypolone 具有抗真菌活性。 |