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Cat. No. Product Name Target Signaling Pathways
T1992 Mertansine

DM1,Maytansinoid DM1

Microtubule Associated Cytoskeletal Signaling
Mertansine (DM1) 是一种微管蛋白抑制剂,也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上,形成抗体偶联药物。
T21408 DM1-SMe

DM1-SSMe

Microtubule Associated Cytoskeletal Signaling
DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍,在一组人类肿瘤细胞系中,DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T17832 DM1-PEG4-DBCO

Others Others
DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.
T17793 DBCO-PEG4-Ahx-DM1

Others Others
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that combines the microtubulin inhibitor DM1 (mertansine), which is an antibody-conjugatable maytansinoid designed to reduce systemic toxicity and improve tumor-specific delivery, with the linker DBCO-PEG4-Ahx, for the development of antibody drug conjugates (ADCs).

化合物

Mertansine
Cat.No: T1992
Synonym: DM1,Maytansinoid DM1
Target: Microtubule Associated
DM1-SMe
Cat.No: T21408
Synonym: DM1-SSMe
Target: Microtubule Associated
DM1-PEG4-DBCO
Cat.No: T17832
Synonym:
Target: Others
DBCO-PEG4-Ahx-DM1
Cat.No: T17793
Synonym:
Target: Others
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