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重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38976	MUC1, mucin core MUC1, mucin core
	MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.
T80919	Tumour-associated MUC1 epitope
	Tumour-associated MUC1 epitope是一种具有标志性的生物活性肽。作为高度糖基化的I型跨膜糖蛋白MUC1的一部分，该肽通过特定的胞外结构域展现，该结构域包含20个氨基酸组成的可变数量串联重复序列(VNTR)。在多种人类腺癌及血液恶性肿瘤（如多发性骨髓瘤和B细胞淋巴瘤）中细胞表面表达过量，因此，MUC1是许多免疫治疗策略的关键靶点。
T35351L	GO-203 acetate GO-203 acetate (1222186-26-6 Free base)	Others	Others
	GO-203 acetate 是一种有效的 MUC1-C 癌蛋白抑制剂。 GO-203 acetate 对细胞内蛋白质表现出抗癌活性。
TP1166	ZINC77292789 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH,Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Others	Others
	ZINC77292789 (Fmoc-Thr[GalNAc(Ac)3-α-D]-OH) 是制备基于三聚体 MUC1 免疫显性基序抗原的候选抗癌疫苗的起始材料，可制备含有 βGalNAc-Thr 作为 Tn 抗原异构体的合成 MUC1 糖肽，可诱导针对肿瘤细胞的抗体产生。
T77191	Clivatuzumab	Others	Others
	Clivatuzumab为人源化抗粘液素单抗，可靶向大部分胰腺癌细胞表面高表达的MUC1表位，对多种肿瘤细胞均有较好的治疗效果。
T78311	Sontuzumab huHMFG-1,AS1402
	Sontuzumab (AS1402)为人源IgG1κMUC1特异性单克隆抗体，其结合细胞外MUC1肽序列PDTR，亲和常数（Kd）约为1 nM。该抗体主要应用于乳腺癌的研究。
T78010	L-GO-203 TFA
	L-GO-203 TFA是针对MUC1-C癌蛋白的有效抑制剂，属于靶向细胞内蛋白的抗癌肽。
T78318	Gatipotuzumab PankoMab
	Gatipotuzumab (PankoMab)为人源化单克隆抗体，专一识别黏蛋白-1的肿瘤特异性表位(TA-MUC1)，并展现出有效的肿瘤特异性抗体依赖细胞毒性(ADCC)。
T35351	GO-203	Others	Others
	GO-203是一种D 型氨基酸肽段，具有细胞通透性，抑制MUC1-C 二聚化，因而抑制其致瘤作用。

化合物

MUC1, mucin core

Cat.No: T38976

Synonym: MUC1, mucin core

Target:

Tumour-associated MUC1 epitope

Synonym: GO-203 acetate (1222186-26-6 Free base)

Target: Others

ZINC77292789

Cat.No: TP1166

Synonym: Fmoc-Thr[GalNAc(Ac)3-α-D]-OH,Fmoc-Thr(Ac₃AcNH-α-Gal)-OH

Synonym: huHMFG-1,AS1402

Synonym: PankoMab

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02005	Mucin-1/MUC1 Protein, Human, Recombinant (hFc) PEM,ADMCKD1,CA15-3,CD227,MCD,muci...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42 kDa and the accession number is P15941-11.
TMPY-04340	Mucin-1/MUC1 Protein, Human, Recombinant mucin 1, cell surface associated,MUC	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.4 kDa and the accession number is P15941-11.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) PEMT,Episialin,Mucin1,PUM,KL-6,MUC	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
TMPY-06832	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His) PEM,MUC-1,EMA,H23AG,Mucin 1	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.19 kDa and the accession number is P15941-1.
TMPY-06833	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) MUC1/ZD,MUC-1,MUC	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.28 kDa and the accession number is P15941-1.
TMPY-02871	Mucin-1/MUC1 Protein, Human, Recombinant (mFc) mucin 1, cell surface associated,ADMCKD	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41 kDa and the accession number is P15941-11.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-00155	Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated Polymorphic epithelial mucin,KL-6,Cancer antigen	Human	HEK293 Cells
	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane ...
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPH-01706	Mucin-16/MUC16 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is Q8WXI7.
TMPK-01394	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) CA125,MUC16,CA125MUC...	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 76.17 kDa and the accession number is Q8WXI7.
TMPK-01365	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated CA-125,FLJ14303,CA125,CA1	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.98 kDa and the accession number is Q8WXI7.
TMPJ-00565	Mucin-15/MUC15 Protein, Human, Recombinant (His) MUC15,Mucin-15,MUC	Human	HEK293 Cells
	Mucin-15 is a single-pass type I membrane protein member of the Mucin family. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans. A key characteristic of Mucins is their ability to form gels. Therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. Mucin-15 is expressed in many tissues. Mucin-15 is highly glycosylat...
TMPK-01366	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated CA125,CA-125,MUC16,FLJ	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPJ-01432	CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated mucin 16, cell surface associated,CA-1...	Human	HEK293 Cells
	MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC...
TMPY-06614	CA125/MUC16 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1.
TMPJ-01456	Mucin-17/MUC17 Protein, Human, Recombinant (His) Mucin-17, MUC-17, MU...	Human	HEK293 Cells
	Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. And that p38 signalling is a key factor involved in MUC17-mediated inhibition of GC cell proliferation and protection against inflammatory stimulation, MUC17 upregulates the expression ...
TMPK-01359	CA125/MUC16 Protein, Human, Recombinant (His & Avi) MUC16,CA-125,CA125,FLJ	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPK-00286	Siglec-9 Protein, Human, Recombinant (His & Avi) SIGLEC9,FOAP-9,CDw329,Siglec-9,CD329,OBBP-Like	Human	HEK293 Cells
	Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Siglec-9 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.9 kDa and the accession number is Q9Y3...
TMPK-00287	Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated CDw329,FOAP-9,SIGLEC9,CD329,Siglec-9,OBBP-Like	Human	HEK293 Cells
	Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.9 kDa and the accession ...

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