Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13782 |
MS432
|
MEK | MAPK |
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. | |||
T82378 |
Folate-MS432
|
PROTACs | PROTAC |
Folate-MS432作为PROTAC,通过叶酸受体依赖途径特异性降解癌细胞中的MEKs。 | |||
T17638 |
Boc-11-aminoundecanoic acid
|
Others; PROTAC Linker | Others; PROTAC |
Boc-11-aminoundecanoic acid 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于 MS432 的合成。 | |||
T40233 |
(Iso)-MS4322
(Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer) |
Histone Methyltransferase | Chromatin/Epigenetic |
(Iso)-MS4322 ((Iso)-YS43-22) 是一种具有选择性和强效性的蛋白质精氨酸甲基转移酶 5 (PRMT5) 降解剂,具有潜在的抗癌活性,有效地降低 MCF-7 细胞中的 PRMT5 蛋白水平,可抑制多种癌细胞的生长。 | |||
T17694 |
Br-C10-methyl ester
11-溴代十一烷酸甲酯 |
Others; PROTAC Linker | Others; PROTAC |
Br-C10-methyl ester 是一种属于 alkyl/ether 类的 PROTAC linker,可用于一系列 PROTAC 分子的合成。PROTAC 分子含有两个通过 linker 连接的不同配体,一种是 VHL 配体部分,另一种是靶蛋白配体。 | |||
T18668 |
(S,R,S)-AHPC-Me-C10-Br
|
Others | Others |
(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1]. | |||
T18669 |
(S,R,S)-AHPC-Me-C10-NH2
|
Others | Others |
(S,R,S)-AHPC-Me-C10-NH2 is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate that incorporates both a VHL ligand and a linker. This compound, (S,R,S)-AHPC-Me-C10-NH2, finds application in PROTAC MS432[1]. |