Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70692 |
ST7612AA1
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
ST7612AA1 是一种新型有效且可口服的 HDAC 抑制剂,作为作为HIV-1潜伏期再激活剂。ST7612AA1 在体内外实验中低浓度显示出显著的抗肿瘤活性。ST7612AA1 具有潜在的抗癌活性,可用于研究疟疾。 | |||
T70693 |
MRT-92 HCl salt
|
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MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain. |