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Search Results for " mmp-12 "

Targets Recommended: MMP

16

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60083	MMP-12 Inhibitor MMP12,MMP408	MMP	Proteases/Proteasome
	MMP-12 Inhibitor 是一种选择性的 MMP-12 抑制剂，对人、小鼠、大鼠和绵羊 MMP-12 的 IC50 分别为 2、160、320 和 22.3 nM。
T83168	Aderamastat FP-003,FP-025	MMP	Proteases/Proteasome
	Aderamastat (FP-025) 是一种具有口服活性的基质金属蛋白酶12（MMP-12）抑制剂，适用于过敏性哮喘、COPD与肺纤维化的研究。
T12414	PF-00356231 hydrochloride	MMP	Proteases/Proteasome
	PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂，IC50 为 1.4 μM。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T28633	RXP470 RXP470.1,RXP 470,RXP-470.1,RXP 470.1,RXP-470
	RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).
T13249	UK-370106	MMP	Proteases/Proteasome
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
T62090	(Rac)-Tanomastat
	Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂，能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中，Tanomastat 表现出抗侵袭和抗转移作用。
T60071	PF 00356231	MMP	Proteases/Proteasome
	PF 00356231 是一种特异性抑制剂 MMP-12，可用于治疗肺气肿和慢性阻塞性肺病 (COPD) 的研究。
T60551	MMP2-IN-2
	MMP2-IN-2 (化合物 42) 是一种有效且选择性的MMP-2(基质金属蛋白酶)抑制剂，其IC50值为 4.2 μM。它对MMP-13、MMP-9和MMP-8也具有抑制活性，IC50值分别为 12、23.3 和 25 μM。
T69230	AZD-1236
	AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ...
T37983	GM 1489
	GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor...
T80242	TNO211	MMP	Proteases/Proteasome
	TNO211为具备生物活性的肽，主要研究对象是基质金属蛋白酶（MMP），一类能够降解多种细胞外基质蛋白并调控诸多生物活性分子的肽链内切酶家族。MMP在细胞表面受体裂解、凋亡配体释放及趋化因子/细胞因子失活等过程中起作用，同时与细胞增殖、迁移（粘附/分散）、分化、血管生成、细胞凋亡及宿主防御等生物行为密切相关。TNO211可靶向MMP-2、8、12、13和14，包含MMP特定可裂解的Gly-Leu键，并具有EDANS/DABCYL荧光标记，其荧光检测在监测内皮细胞培养基和患者滑液中的MMP活性方面表现出高灵敏度。吸光度/电磁场测量参数为340/490 nm。
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

MMP-12 Inhibitor

Cat.No: T60083

Synonym: MMP12,MMP408

Target: MMP

Cat.No: T83168

Synonym: FP-003,FP-025

Target: MMP

PF-00356231 hydrochloride

Cat.No: T12414

Target: MMP

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T27654

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

Cat.No: T28633

Synonym: RXP470.1,RXP 470,RXP-470.1,RXP 470.1,RXP-470

Cat.No: T13249

Target: MMP

(Rac)-Tanomastat

Cat.No: T62090

Cat.No: T60071

Target: MMP

Cat.No: T60551

Cat.No: T69230

Cat.No: T37983

Cat.No: T80242

Target: MMP

Cat.No: T68321

Cat.No: T37861

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase ...	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPJ-00942	MMP-12 Protein, Mouse, Recombinant (His) Mme,Mmp12,MMP-12,Mmel,Ma...	Mouse	HEK293 Cells
	Matrix metalloproteinase-12（MMP12） is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
TMPH-01633	MMP-12 Protein, Human, Recombinant (His)	Human	E. coli
	May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. MMP-12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P39900.
TMPY-02642	UBE2W Protein, Human, Recombinant (His) UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative)	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th...
TMPY-00479	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) ARIA,neuregulin 1,GGF2,MSTP131,GGF,MST131,HGL,NDF,SMDF,HRG1,...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.
TMPY-03797	Neurofascin Protein, Human, Recombinant (His) neurofascin,NF,NRCAML	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.4 kDa and the accession number is O94856-12.
TMPY-04620	Neurofascin Protein, Human, Recombinant (hFc) neurofascin,NRCAML,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-12.
TMPY-00031	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) HRG1,GGF2,HRG,NDF,MSTP131,HRGA,GGF,neuregulin 1,HGL,SMDF,ARI...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is Q02297-12.

重组蛋白

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

MMP-12 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00942

Species: Mouse

Expression System: HEK293 Cells

MMP-12 Protein, Human, Recombinant (His)

Cat.No: TMPH-01633

Species: Human

Expression System: E. coli

UBE2W Protein, Human, Recombinant (His)

Cat.No: TMPY-02642

Species: Human

Expression System: E. coli

Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00479

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (His)

Cat.No: TMPY-03797

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04620

Species: Human

Expression System: HEK293 Cells

Neuregulin-1/NRG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00031

Species: Human

Expression System: HEK293 Cells

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