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Search Results for " ml-128 "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6726	VU0361737 ML-128,VU 0361737	GluR	Neuroscience
	VU0361737 (ML-128) 是一种高效选择性的，中枢神经系统渗透性的代谢型谷氨酸受体 4(mGluR4)正变构调节剂，对人类和大鼠 mGluR4作用的EC50值分别为 240 和 110 nM。它具有神经保护作用，有用于帕金森氏病的研究潜力。
T61142	Antitubercular agent-17
	Antitubercular agent-17 (Compound 8a) 是一种抗结核剂，对 M. tuberculosisH37Rv、Spec. 192、Spec 210 和 Spec. 800 的 MIC 值分别为 2、2、2 和 128 μg/ml。Antitubercular agent-17 表现出高选择性的抗分支杆菌效果。
T61649	ATP synthase inhibitor 2
	ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。
T75001	Antibacterial agent 128
	Antibacterial agent 128 是一种带有可裂解接头的铁载体类似物-环丙沙星 (Ciprofloxacin (Ciprofloxacin )) 偶联物。Antibacterial agent 128 显示出针对铜绿假单胞菌 (MIC 值为 0.25-64 μg/mL) 和类鼻疽伯克氏菌 (MIC 值为 1-32 μg/mL) 的抗生素活性。
T29175	YKAs3003 YKAs-3003
	YKAs3003, a potent inhibitor of pathogenic KAS III, displays minimal inhibitory concentration (MIC) values in the range 128-256 microg/mL against various bacteria.
T79004	ATP synthase inhibitor 2 TFA
	ATP synthase inhibitor2 (Compound 22) TFA 为针对铜绿假单胞菌 (PA) ATP synthase 的抑制剂，具IC50值为10 μg/mL，在浓度达到128 μg/mL 时能够全面阻断铜绿假单胞菌 (PA) ATP的合成活性。
T80091	Ranalexin
	Ranalexin为一抗菌肽，对金黄色葡萄球菌、大肠杆菌及铜绿假单胞菌的最小抑菌浓度(MIC)分别为4、32、128 μg/mL。
T38917	Antibacterial agent 50
	Antibacterial agent 50 (example 47) is a compound that exhibits antibacterial activity. It shows minimum inhibitory concentration (MIC) values of 32, 64, and 128 mcg/mL against three strains of E. coli, namely NCTC 13351, M 50, and 7 MP, respectively (WO2013030733A1).
T61143	Antitubercular agent-18
	Antitubercular agent-18 (Compound 9a) 为抗结核剂，对M. tuberculosisH37Rv、Spec. 192、Spec 210 及 Spec. 800 的最小抑制浓度(MIC)值依次为2、2、2 及128 μg/ml，展现出对分支杆菌的高选择性抗菌活性。
T61783	Antimicrobial agent-1
	Antimicrobial Agent-1 (compound 6C) shows strong activity (MIC = 2 μg/mL) against TolC mutant E. coli. Additionally, it synergistically interacts with Colistin to exhibit enhanced activity against Gram-negative bacteria. Importantly, Antimicrobial Agent-1 exhibits no cytotoxic effects on mammalian cell lines. Its MIC values on Caco-2 and Vero cell lines are greater than 128 μg/mL [1].
T38321	A-39183A
	A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. It has activity against penicillin-resistant S. aureus 3055 and S. faecalis X66 (MICs = 32 and 32 μg/ml, respectively) and a variety of Gram-positive and Gram-negative anaerobic bacteria (MICs = 16-128 μg/ml) in an agar dilution assay.
T37553	(-)-Mycousnine
	(-)-Mycousnine is a microbial metabolite and derivative of usnic acid originally isolated fromM. nawaethat has antibacterial and antifungal activities.1,2It is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andS. aureus(MICs = 4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteriaE. coli,S. typhimurium, andK. pneumoniae(MICs = >128 g/ml for all).2(-)-Mycousnine is also active against the fungiT. mentagrophytes,T. rubrum, andC. albicans(MICs = 25, 25, and 100 μg/m...
T80276	Lynronne-3
	Lynronne-3 是一种具有抗革兰氏阳性细菌活性的抗菌肽，涵盖 MDR 菌株（对MRSA菌株的 MIC 为 32-128 μg/mL）。此外，Lynronne-3 亦对 P. aeruginosa 感染显示出效力。
T80376	GP-2B
	GP-2B是一种具有针对革兰氏阳性菌株抗菌活性的抗菌肽，其最小抑菌浓度(MIC)针对金黄色葡萄球菌和粪肠球菌为8-128μg/mL。
T83921	IMCTA-C14 TFA
	IMCTA-C14是一种洗涤剂且是微生物代谢产物4-糖腺苷的衍生物。其临界胶束浓度(CMC)为0.11 mM，亲水亲油平衡(HLB)值为9.72。IMCTA-C14（0.05%和0.5%）能从OVK18卵巢癌细胞提取蛋白质，包括膜蛋白。它对几种不同菌株具有活性（MICs = 8-128 µg/ml），并对52种癌细胞系具有细胞毒性（IC50s = 2.9-29.2 µg/ml）。IMCTA-C14（50 µM）诱导OVK18细胞的自噬。
T36746	Leoidin
	Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM...
T35426	β-Defensin-1 (human) (trifluoroacetate salt)
	β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no...

化合物

Cat.No: T6726

Synonym: ML-128,VU 0361737

Target: GluR

Antitubercular agent-17

Cat.No: T61142

ATP synthase inhibitor 2

Cat.No: T61649

Antibacterial agent 128

Cat.No: T75001

Cat.No: T29175

Synonym: YKAs-3003

ATP synthase inhibitor 2 TFA

Cat.No: T79004

Cat.No: T80091

Antibacterial agent 50

Cat.No: T38917

Antitubercular agent-18

Cat.No: T61143

Antimicrobial agent-1

Cat.No: T61783

Cat.No: T38321

Cat.No: T37553

Cat.No: T80276

Cat.No: T80376

Cat.No: T83921

Cat.No: T36746

β-Defensin-1 (human) (trifluoroacetate salt)

Cat.No: T35426

Cat. No.	Product Name	Target	Signaling Pathways
TN2281	Sinapaldehyde trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛	Antibacterial	Microbiology/Virology
	Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用，MIC 值都为 128 μg/mL。
TN1165	(Rac)-Myrislignan 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟	Others	Others
	1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC

天然产物

Cat.No: TN2281

Synonym: trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛

Target: Antibacterial

(Rac)-Myrislignan

Cat.No: TN1165

Synonym: 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟

Target: Others

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