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Cat. No. | Product Name | Target | Signaling Pathways |
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TP2270 |
MHC class II antigen (45-57) [Homo sapiens]
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Others | Others |
MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l | |||
T73133 |
FGF22-IN-1
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Others | Others |
FGF22-IN-1 是一种潜在的 CD4 N-末端免疫球蛋白可变区样结构域(CD4 D1)抑制剂。FGF22-IN-1 可抑制CD4 与主要组织相容性复合体 (MHC) II 类蛋白之间的相互作用,抑制免疫应答。 | |||
TP1126 |
InsB 9-23
Insulin B chain (9-23) |
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InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. | |||
T36116 | Concanamycin B | ||
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su... | |||
T40115 |
GAD65 (206-220)
GAD65 (206-220) |
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GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus. | |||
T40590 |
NY-ESO-1 (87-111)
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NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide that interacts with various HLA-DR and HLA-DP4 molecules, inducing activation of CD4+ T cells with Th1-type and Th-2/Th0-type responses, when presented in conjunction with HLA-DR and HLA-DP4 molecules. | |||
T82743 |
CFP10 (71–85)
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CFP10 (71–85) 是具生物活性的肽类,能激活表达不同MHC II类与I类分子的人类CD4+和CD8+ T细胞,诱导IFN-γ产生及CTL活性。(CFP10 71–85). | |||
T82414 |
Favezelimab
MK-4280 |
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Favezelimab(MK-4280)为人源化抗LAG-3单克隆抗体,能够抑制LAG-3与其配体MHC II类结合。该抗体联合PD-L1抑制剂Pembrolizumab在结直肠癌(CRC)治疗研究中展现出应用前景。 | |||
T78332 |
Eftilagimod alfa
IMP321,LAG-3Ig |
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Eftilagimod alfa为重组LAG-3Ig融合蛋白,具有MHC II 类分子结合能力。该药物通过介导抗原提呈细胞(APC)的激活进而激活CD8 T细胞,可用于研究转移性黑色素瘤及转移性乳腺癌。 | |||
T36984 |
Cyclic di-IMP (sodium salt)
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Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p... | |||
T82071 |
Influenza NP (311-325)
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Influenza NP (311-325) 是具有生物活性的肽段,对应于流感病毒核蛋白(NP)的311至325氨基酸。作为MHC II类限制性表位,它用于研究宿主在感染期间的免疫响应。该肽能在细胞内细胞因子检测中诱导强烈的γ干扰素(IFN-γ)产生,但不激活小鼠CD8 T细胞。谷氨酰胺(Q)或谷氨酸(E)位于N端时,焦谷氨酰(pGlu)肽可自发形成。Q或E向pGlu的自然转化及其疏水性γ-内酰胺环在肽的胃肠道蛋白酶稳定性中可能起作用。焦谷氨酰肽作为常见肽的一部分,在HPLC分析中评估肽的纯度。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0948L |
Corticosterone
皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants) |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇,有盐皮质激素和糖皮质激素的活性,具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。 |