Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12030 |
MG 1
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
MG 1是一种有效的 α1肾上腺素能受体拮抗剂。 | |||
T8780 |
AMG131
INT-131,AMG-131,CHS 131 |
PPAR | DNA Damage/DNA Repair; Metabolism |
AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂,可用于治疗 2 型糖尿病。 | |||
T70391 |
AMG151 HCl
|
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ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse... | |||
T71793 |
CDMG1
|
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CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population |