Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4231 |
MD2-IN-1
|
TLR | Immunology/Inflammation |
MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 为 189 μM。 | |||
T7672 |
MD2-TLR4-IN-1
|
TLR | Immunology/Inflammation |
MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂,能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达,IC50值分别为 0.89 和 0.53 μM。 | |||
T37816 |
SB 243213
|
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SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. SB 243213 shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows... | |||
T74799 | NF-κB-IN-8 | NF-κB | NF-κB |
NF-κB-IN-8 是一种化合物,其作用机制为竞争性抑制 LPS 与 MD-2 之间的相互作用。该化合物通过与 MD-2 结合,有效降低炎症因子的产生,并能够抑制 ALP 的酶活性。因此,NF-κB-IN-8 在急性肺损伤(ALI)等炎症性疾病的研究中具有潜在应用价值。 | |||
T35687 |
Collismycin A
|
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Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc... |