Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78848 |
MAO-IN-3
|
Monoamine Oxidase | Neuroscience |
MAO-IN-3 (Compound 5) 为一种可逆竞争性MAO抑制剂,Ki值对MAO A为0.6 μM、对MAO B为0.2 μM。该化合物能抑制LN-229胶质母细胞瘤细胞增殖,其IC50为0.8 μM,适用于癌症研究。 | |||
T39986 |
LOX-IN-3 dihydrochloride
|
Lipoxygenase | Metabolism |
LOX-IN-3 dihydrochloride 是口服有效的赖氨酰氧化酶抑制剂,在纤维化,癌症和/或血管生成方面有研究价值。 | |||
T78648 |
MAO-B-IN-3
|
Monoamine Oxidase | Neuroscience |
MAO-B-IN-3是一种选择性MAO-B抑制剂,具有可逆性,IC50为96 nM。该化合物还可与5-HT6R结合,Ki值为696 nM,适用于阿尔茨海默病研究。 | |||
T72791 |
AChE/MAO-B-IN-3
|
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AChE/MAO-B-IN-3 是AChE 和MAO-B 的抑制剂,对人AChE 和MAO-B 的IC50分别为 0.0257 μM 和 0.0456 μM。AChE/MAO-B-IN-3 可用于阿尔兹海默症的研究。 | |||
T72453 |
AChE/BChE/MAO-B-IN-3
|
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AChE/BChE/MAO-B-IN-3 是一种 1-茚满酮衍生物,是一种有效的MAO-B 抑制剂,对人MAO-B 的IC50为 0.0359 μM。AChE/BChE/MAO-B-IN-3 是一种有效的AChE 和BChE 酶抑制剂,对人AChE 和BChE 酶的IC50值分别为 0.0473 μM 和 0.0782 μM。AChE/BChE/MAO-B-IN-3 显示出显着的抗氧化活性,并具有用于阿尔茨海默病 (AD) 研究的潜力。 | |||
T74991 | Dual AChE-MAO B-IN-3 | ||
Dual AChE-MAO B-IN-3 (compound C10) 是一种有效的双AChE/MAO-B 抑制剂,IC50值分别为 0.58 和 0.41 μM。Dual AChE-MAO B-IN-3 是一种双结合抑制剂,能与AChE 的催化阴离子位点和外周阴离子位点结合。Dual AChE-MAO B-IN-3 可以用于阿尔茨海默病 (AD) 的研究。 | |||
T4410 |
LM10
|
Others | Others |
LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶,它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。 | |||
T61139 | HDAC6-IN-3 | ||
HDAC6-IN-3 (Compound 14) is a potent anti-prostate cancer agent that acts as an orally active inhibitor of HDAC6. It has IC50 values ranging from 0.02-1.54 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10. Additionally, HDAC6-IN-3 also demonstrates effective inhibition of MAO-A (IC50 = 0.79 μM) and LSD1 [1]. | |||
T79299 |
hAChE-IN-3
|
Monoamine Oxidase | Neuroscience |
hAChE-IN-3(compounds 5c)是一种穿透血脑屏障的有效AChE、BuChE、MAO-B-IN-1和BACE-1抑制剂,IC50值依次为0.44、0.08、5.15和0.38μM。该化合物展现出抗氧化特性和金属离子螯合作用,能结合外周阴离子位点,干预Amyloid-β(Aβ)的聚集,减轻与阿尔兹海默症相关的神经退行性变化,适用于阿尔兹海默症的研究。 | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
||
Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T75339 |
Methylene blue hydrate
|
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亚甲蓝(Basic Blue 9)水合物,作为鸟苷酸环化酶(sGC)、单胺氧化酶A(MAO-A)及NO合酶(NOS)的抑制剂,常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶/鸟苷酸环化酶信号通路,能够减少脉冲前抑制,同时作为一种氧化还原循环化合物,具有穿透血脑屏障的能力,并作为Tau蛋白聚集的抑制剂,有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。 | |||
T35712 |
Debutyldronedarone hydrochloride
SR35021 hydrochloride |
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N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h... |