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8

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40555	LyP-1
	LyP-1 is a cyclic peptide comprised of 9 amino acids, designed to target and bind selectively to p32 receptors that are overexpressed in a range of tumor-associated cells.
T40555L	LyP-1 acetate LyP-1 acetate (454487-07-1 Free base)	Others	Others
	LyP-1 acetate 是一种肿瘤定位肽，可特异性结合在各种肿瘤相关细胞中过表达的 p32 受体。
T38834	LYP-IN-1
	LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders.
T78017	LyP-1 TFA
	LyP-1 TFA是一种环肽，由9个氨基酸组成，特异性地与多种肿瘤相关细胞中的p32 receptor蛋白结合，起到定位肿瘤的作用。
T16423	p32 Inhibitor M36 M36	Others	Others
	p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.
T79634	LYP-IN-3	Phosphatase	Metabolism
	LYP-IN-3（compound D34）作为一种淋巴酪氨酸磷酸酶（LYP）的选择性抑制剂（Ki=0.93 μM），通过调节T细胞受体（TCR）信号通路发挥在肿瘤进展中的作用。它能够激活T细胞，抑制M2型巨噬细胞的极化，并上调PD-1/PD-L1表达，适合与PD-1/PD-L1抑制剂联合使用，为癌症免疫治疗提供进一步的疗效潜力。
T79635	LYP-IN-4	Phosphatase	Metabolism
	LYP-IN-4（compound D14）是一种针对淋巴酪氨酸磷酸酶（LYP）的可逆且特异性抑制剂，具有Ki值1.34 μM和IC50值3.52 μM。该化合物通过抑制LYP来调控TCR信号传递，并上调PD-1/PD-L1的表达，以此增强抗肿瘤免疫反应。此外，LYP-IN-4能够激活T细胞、抑制M2型巨噬细胞的极化，并在MC38同基因小鼠模型中抑制肿瘤生长。
T11889	LTV-1	Others	Others
	LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.

化合物

Cat.No: T40555

LyP-1 acetate

Cat.No: T40555L

Synonym: LyP-1 acetate (454487-07-1 Free base)

Target: Others

Cat.No: T38834

Cat.No: T78017

p32 Inhibitor M36

Cat.No: T16423

Synonym: M36

Target: Others

Cat.No: T79634

Target: Phosphatase

Cat.No: T79635

Target: Phosphatase

Cat.No: T11889

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T19087	1-Arachidoyl-sn-glycero-3-phosphocholine	Others	Others
	1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

天然产物

1-Arachidoyl-sn-glycero-3-phosphocholine

Cat.No: T19087

Target: Others

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