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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40555L |
LyP-1 acetate
LyP-1 acetate (454487-07-1 Free base) |
Others | Others |
LyP-1 acetate 是一种肿瘤定位肽,可特异性结合在各种肿瘤相关细胞中过表达的 p32 受体。 | |||
T40555 |
LyP-1
|
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LyP-1 is a cyclic peptide comprised of 9 amino acids, designed to target and bind selectively to p32 receptors that are overexpressed in a range of tumor-associated cells. | |||
T38834 | LYP-IN-1 | ||
LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders. | |||
T78017 |
LyP-1 TFA
|
||
LyP-1 TFA是一种环肽,由9个氨基酸组成,特异性地与多种肿瘤相关细胞中的p32 receptor蛋白结合,起到定位肿瘤的作用。 | |||
T16423 |
p32 Inhibitor M36
M36 |
Others | Others |
p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1. | |||
T79634 |
LYP-IN-3
|
Phosphatase | Metabolism |
LYP-IN-3(compound D34)作为一种淋巴酪氨酸磷酸酶(LYP)的选择性抑制剂(Ki=0.93 μM),通过调节T细胞受体(TCR)信号通路发挥在肿瘤进展中的作用。它能够激活T细胞,抑制M2型巨噬细胞的极化,并上调PD-1/PD-L1表达,适合与PD-1/PD-L1抑制剂联合使用,为癌症免疫治疗提供进一步的疗效潜力。 | |||
T79635 |
LYP-IN-4
|
Phosphatase | Metabolism |
LYP-IN-4(compound D14)是一种针对淋巴酪氨酸磷酸酶(LYP)的可逆且特异性抑制剂,具有Ki值1.34 μM和IC50值3.52 μM。该化合物通过抑制LYP来调控TCR信号传递,并上调PD-1/PD-L1的表达,以此增强抗肿瘤免疫反应。此外,LYP-IN-4能够激活T细胞、抑制M2型巨噬细胞的极化,并在MC38同基因小鼠模型中抑制肿瘤生长。 | |||
T11889 | LTV-1 | Others | Others |
LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19087 |
1-Arachidoyl-sn-glycero-3-phosphocholine
|
Others | Others |
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP). |