Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21763 |
Lenalidomide hydrochloride
|
Others | Others |
Lenalidomide hydrochloride (CC-5013 hydrochloride) 是 Thalidomide 的衍生物,也是一种具有口服活性免疫调节剂,以分子胶的方式作用。Lenalidomide hydrochloride (CC-5013 hydrochloride) 是一种泛素 E3 连接酶 cereblon (CRBN) 的配体,通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。Lenalidomide hydrochloride (CC-5013 hydrochloride) 特异性抑制成熟 B 细胞淋巴瘤 (包括多发性骨髓瘤) 的生长,并诱导 T 细胞释放白细胞介素-2 (IL-2)。 | |||
T38545 |
Lenalidomide-5-aminomethyl hydrochloride
|
Others | Others |
Lenalidomide-5-aminomethyl hydrochloride is a cereblon (CRBN) ligand derived from Lenalidomide. It serves as a ligand for the recruitment of the CRBN protein. When connected to the protein via a linker, Lenalidomide-5-aminomethyl hydrochloride forms a PROTAC. | |||
T40547 |
Lenalidomide-4-aminomethyl hydrochloride
|
Others | Others |
Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated. | |||
T18070 |
Lenalidomide-propargyl-C2-NH2 hydrochloride
|
Others | Others |
Lenalidomide-propargyl-C2-NH2 hydrochloride is a compound that features a cereblon (CRBN) ligand for the E3 ubiquitin ligase, as well as a linker. It is utilized in the development of the PROTAC MD-224[1] system. | |||
T17878 |
Lenalidomide-C4-NH2 hydrochloride
Cereblon ligand 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 32 hydrochloride |
Others | Others |
Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1]. | |||
T18069 |
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride
|
Others | Others |
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound that features a cereblon (CRBN) ligand, functioning as an E3 ubiquitin ligase, along with a linker. It can be utilized to create the PROTAC MD-224[1]. | |||
T74002 | SJF620 hydrochloride | PROTACs | PROTAC |
SJF620 hydrochloride,作为一种连接Cereblon配体和Btk配体的PROTAC,具备DC50值为7.9 nM。该化合物含Lenalidomide类似物,能有效募集CRBN。 |