Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6280 |
Enzastaurin
LY317615,恩扎妥林 |
Apoptosis; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling |
Enzastaurin (LY317615) 是一种PKCβ抑制剂,IC50值为 6 nM。它对 PKCβ 选择性是 PKCα,PKCγ 和 PKCε 的 6-20 倍。 | |||
T69354 |
Enzastaurin 2HCl
|
||
Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. | |||
T71853 |
Enzastaurin HCl
|
||
Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. |