Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60360 | LSD1/2-IN-3 | ||
LSD1/2-IN-3 是赖氨酸特异性去甲基化酶 1 (LSD1) 的选择性抑制剂,Ki 值是 11 nM,而对LSD2的 Ki 值为 7 μM。LSD1在肿瘤干细胞中异常表达,LSD1/2-IN-3 能够抑制LSD1活性和癌细胞增殖。 | |||
T82254 |
GSK-LSD1
|
Histone Demethylase | Chromatin/Epigenetic |
GSK-LSD1是一种LSD1抑制剂,能够降低肥胖小鼠模型的摄食量和体重,同时提升胰岛素敏感性与血糖控制。此外,GSK-LSD1对NAFLD也有改善作用,并能抑制COVID-19患者PBMC中SARS-CoV-2诱导的细胞因子释放。GSK-LSD1对抑制癌症的生长与转移也显示出潜在效果。 | |||
T36668 |
Geranylgeranoic Acid
|
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Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also... |