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Search Results for " lox1 "

Targets Recommended: Lipoxygenase

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T62606	ALOX15-IN-2	Lipoxygenase	Metabolism
	ALOX15-IN-2 是一种有效的 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂，抑制ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA)进行氧化作用， IC50 分别为 1.55 和 2.79 μM。
T63075	ALOX15-IN-1
	ALOX15-IN-1 (compound 8b) 是一种选择性的、有效的兔和人 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂，能够作用于 ALOX15 直系同源物亚油酸 (LA) (IC50: 0.04 μM) 和花生四烯酸 (AA) (IC50: 2.06 μM)。
T77288	KKII5	Lipoxygenase	Metabolism
	KKII5 是一种有效的脂氧合酶 LOX-1 抑制剂，IC50 为 19 μM。KKII5 抑制脂质过氧化，增强部分化合物活性中心接收电子的能力。
T67908	ThioLox	Lipoxygenase	Metabolism
	ThioLox 是一种竞争性 15-脂氧合酶-1 (15-LOX-1) 抑制剂(IC50值为12 μM)。ThioLox 显示抗炎和神经保护特性。具有抗炎和神经保护作用，对谷氨酸毒性有很强的保护作用。
T67870	DKI5 (E)-N'-benzylidenehydrazinecarbothiohydrazide	Lipoxygenase	Metabolism
	DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) 是一种 LOX-1 抑制剂，IC50 值为 22.5 μM。DKI5 可能具有抗炎和抗氧化活性，在体外生物测定中显示出抗脂质过氧化活性。
T36169	15-LOX-1 inhibitor 1
	9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.

化合物

ALOX15-IN-2

Cat.No: T62606

Synonym:

Target: Lipoxygenase

Target: Lipoxygenase

ThioLox

Cat.No: T67908

Synonym:

Target: Lipoxygenase

DKI5

Cat.No: T67870

Synonym: (E)-N'-benzylidenehydrazinecarbothiohydrazide

Target: Lipoxygenase

15-LOX-1 inhibitor 1

Cat.No: T36169

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T8260	4',5-Dihydroxyflavone	Lipoxygenase; Glucosidase	Metabolism
	4',5-Dihydroxyflavone 是大豆 LOX-1，Ki=102.6 μM。它也是一种酵母 α-葡萄糖苷酶抑制剂，IC50=66 μM。

天然产物

4',5-Dihydroxyflavone

Cat.No: T8260

Synonym:

Target: Lipoxygenase, Glucosidase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03371	LOX-1 Protein, Rat, Recombinant (hFc) OLR1,Lox1,Oldlr1,oxidize...	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.9 kDa and the accession number is O70156.
TMPY-04066	LOX-1 Protein, Rat, Recombinant (His) oxidized low density lipoprotein (lectin-like) receptor ...	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is O70156.
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His) LOXIN,LOX-1,CLEC8A,Ox-LDL recepto...	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
TMPY-02490	LOX-1 Protein, Human, Recombinant (His) LOXIN,SCARE1,SLOX1,L...	Human	HEK293 Cells
	LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
TMPH-00955	ALOX12 Protein, Human, Recombinant (His) Polyunsaturated fatty acid lipoxygenase ALOX1	Human	E. coli
	ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli.