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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6570	L-NAME hydrochloride L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride	NOS; NO Synthase	Immunology/Inflammation
	L-NAME hydrochloride (L-NAME HCl) 是NOS 抑制剂(IC50:70 μM)。
T25865	NG-Nitroarginine methyl ester ω-Nitroarginine methyl,L-NAME	NO Synthase	Immunology/Inflammation
	NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) 是一种非选择性一氧化氮合酶抑制剂。它已在实验中用于诱发高血压。
T16686	Pyr10	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pyr10 是吡唑衍生物，是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。
T36719	D-NAME (hydrochloride)
	N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 &#181g/mouse) had no effect on no...
T68559	OUN58101
	OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T75137	BAY-747
	BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外，BAY-747在mdx/mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。
T36556	(±)5(6)-DiHET lactone
	5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be b...
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato...
TP1816	Urotensin II, mouse
	Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En

化合物

L-NAME hydrochloride

Cat.No: T6570

Synonym: L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride

Target: NOS, NO Synthase

NG-Nitroarginine methyl ester

Cat.No: T25865

Synonym: ω-Nitroarginine methyl,L-NAME

Target: NO Synthase

Pyr10

Cat.No: T16686

Synonym:

Target: TRP/TRPV Channel

D-NAME (hydrochloride)

(±)5(6)-DiHET lactone

Cat.No: T36556

Synonym:

Target:

9(E),11(E)-12-nitro Conjugated Linoleic Acid

Cat. No.	Product Name	Target	Signaling Pathways
TMS2262	(-)-CAMPHOR L-Camphor,左旋樟脑	Others	Others
	(-)-CAMPHOR (L-Camphor) 是樟脑的手性中间体，在食品中用作风味添加剂和甜味剂。

天然产物

(-)-CAMPHOR

Cat.No: TMS2262

Synonym: L-Camphor,左旋樟脑

Target: Others

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