Cat. No. | Product Name | Target | Signaling Pathways |
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TP1666L |
Kisspeptin-10, rat acetate(478507-53-8 free base)
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GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin-10, rat acetate(478507-53-8 free base) 是啮齿动物 Kisspeptin 受体 (KISS1, GPR54) 的内源性配体。 | |||
TP1896L1 |
Kisspeptin 234 acetate(1145998-81-7 free base)
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GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin 234 acetate(1145998-81-7 free base) 是Kisspeptin 受体 (KISS1, GPR54) 拮抗剂; 是Kisspeptin-10 类似物。它抑制 Kisspeptin-10 对磷酸肌醇 (IP) (IC50 = 7 nM) 的刺激和促性腺激素释放激素 (GnRH) 的释放。 | |||
TP1345 |
Kisspeptin-10, human (TFA)(374675-21-5,FREE)
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GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10,人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化 | |||
TP2010 |
Kisspeptin 10 (dog)
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Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo. | |||
TP1896 |
Kisspeptin 234
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kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH). | |||
T35794 |
Kisspeptin-54 (human) (trifluoroacetate salt)
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Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5... | |||
TP1666 |
Kisspeptin-10, rat
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Endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54). | |||
TP1396 |
Kisspeptin-10, human
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Kisspeptin-10, human is an effective vasoconstrictor and inhibitor of angiogenesis. | |||
TP2005 |
Kisspeptin-54(human)
Metastin (human) |
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Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carci | |||
T76339 |
Kisspeptin 13
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Kisspeptin 13 是一种 GPR54和 GnRH 受体激活剂,是一种内源性的活性异构体。Kisspeptin 13 能增强记忆,可用于阿尔茨海默病的研究。 | |||
T75839 |
Kisspeptin-10, rat TFA
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Kisspeptin-10, rat TFA 作为有效的血管收缩剂及血管生成抑制剂,为GPR54 (亦称KISS1) 亲吻蛋白受体的配体。此外,Kisspeptin-10, rat TFA 能降低Methotrexate引起的生殖毒性并显示出抗氧化潜力。 | |||
T83666 |
Kisspeptin-10 (zebrafish) TFA
Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10 |
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Kisspeptin-10是一种在斑马鱼的大脑、卵巢和睾丸中表达的神经肽,参与性腺发育和类固醇表达。在10 ng/ml的浓度下使用时,能提高孤立的斑马鱼卵巢滤泡中编码黄体生成素(luteinizing hormone, Lh)受体,以及孕酮受体a (Progestin receptor a, Pra)和Prb的mRNA水平。在0.1和1 µg/g的剂量下给予时,Kisspeptin-10能在雌性金鱼中增加黄体生成素的血清水平,但在雄性金鱼中则不会。 | |||
T78106 |
Kisspeptin 234 TFA
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Kisspeptin 234 TFA,作为一种十肽,是kisspeptin受体(KISS1, GPR54)的拮抗剂,并且是Kisspeptin 10的类似物。 | |||
T75774 |
Kisspeptin-54(human) TFA
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Kisspeptin-54(human) TFA (Metastin(human) TFA) 是一种 Kisspeptin 受体 (KISS1,GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54受体,其Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) TFA 可抑制肿瘤转移并刺激促性腺激素分泌。 | |||
T75745 |
Kisspeptin-10, human TFA
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Kisspeptin-10, human TFA为一种有效的血管收缩剂及血管生成抑制剂,通过其受体GPR54抑制肿瘤转移。Kisspeptin-10-GPR54系统对胚胎肾脏发展具有关键影响,而Kisspeptin-10/GPR54信号则通过NFATc4介导的BMP2表达促进成骨细胞分化。 | |||
TP1093 |
TAK-448 acetate
TAK-448 acetate (1234319-68-6 Free base),MVT-602 acetate |
Kisspeptin | GPCR/G Protein |
TAK-448 acetate (MVT-602 acetate) 是一种小分子 KISS1R 激动剂,是一种和 kisspeptin 类似的合成肽。TAK-448 acetate 具有抗肿瘤活性,抑制 VCaP 细胞增殖,可用于研究前列腺癌。 | |||
TP1467 |
KISS1-305
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KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.KISS1-305 is a proto- type peptide that resists plasma protease degradation | |||
T70670 | TAK-448 TFA | ||
TAK-448 is an investigational oligopeptide analog of kisspeptin and a potent agonist of the GPR54 receptor. In animals, acute TAK-448 administration stimulates LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. TAK-448 has exhibited potent antitumor activity in rat androgen-dependent prostate cancer models. Therefore, TAK-448 may be useful in the treatment of PC in humans.. |