Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13320L |
VU591
|
Potassium Channel | Membrane transporter/Ion channel |
VU591 是选择性的肾外髓钾通道抑制剂,IC50为 0.24 μM。 | |||
T13320 |
VU591 hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂,IC50为 0.24 μM。 | |||
T23516 |
VU590
|
Potassium Channel | Membrane transporter/Ion channel |
VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1,可调节子宫肌层收缩力和黑皮质素信号传导。 | |||
T6592 |
ML133 hydrochloride
ML133 HCl,(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 |
Potassium Channel | Membrane transporter/Ion channel |
ML133 hydrochloride (ML133 HCl) 是选择性的Kir2家族通道抑制剂,在pH 7.4 和pH 8.5 时的IC50值分别为1.8 μM 和290 nM。 | |||
TP2113 |
Tertiapin LQ
|
||
Blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q. | |||
T17240 | VU041 | Others | Others |
VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. | |||
TP2114 |
Tertiapin-Q
|
||
A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and | |||
T83749 |
Tertiapin LQ TFA
TPNLQ |
||
Tertiapin LQ是源自蜜蜂毒素肽tertiapin的肽衍生物,同时也是向内整流钾(Kir)通道的抑制剂。它能够抑制由G蛋白激活的向内整流钾通道1(GIRK1)和GIRK4(即Kir3.1和Kir3.4)组成的异源多聚钾通道,以及向内整流钾通道1(Kir1.1)。在活体内,tertiapin LQ抑制在雪貂中对条件刺激的Purkinje细胞暂停响应。 |