5
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15654 |
Ketohexokinase inhibitor 1
PF-06835919 |
Others | Others |
Ketohexokinase inhibitor 1 是一种酮己糖激酶抑制剂(对 KHK-C 和 KHK-A 的 IC50:分别为 8.4 nM 和 66 nM)。 | |||
T15660 |
KHK-IN-1
KHK-IN-8,Ketohexokinase inhibitor 8 |
Others | Others |
KHK-IN-1 (KHK-IN-8) 是一种选择性的、细胞膜渗透性的己酮糖激酶 (KHK) 抑制剂 (IC50=12 nM; F=34%)。KHK-IN-1 抑制 HepG2 细胞裂解液中 F1P 生成,IC50为400 nM。KHK-IN-1 可用于研究糖尿病和肥胖症。 | |||
T11757 |
KHK-IN-2
|
Others | Others |
KHK-IN-2是一种选择性的酮基己酸酶抑制剂,IC50值为0.45μM。 | |||
T15659 |
KHK-IN-1 hydrochloride
|
Others | Others |
KHK-IN-1 hydrochloride is a potent inhibitor of ketohexokinase (KHK) (IC50: 12 nM). In the ATP-binding region of KHK, KHK-IN-1 hydrochloride interacts with Asp-27B. | |||
T81982 |
KHK-IN-4
|
||
KHK-IN-4(compound 14)是一种针对酮己糖激酶(KHK)的高效抑制剂,适用于果糖代谢疾病的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00479 |
KHK Protein, Human, Recombinant (His)
KHK,Hepatic fructokinase,Ketohexokinase |
Human | HEK293 Cells |
Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria. | |||
TMPH-02747 |
Ketohexokinase/KHK Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Ketohexokinase/KHK Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPH-01585 |
Ketohexokinase/KHK Protein, Human, Recombinant (GST)
|
Human | E. coli |
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Ketohexokinase/KHK Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 59.7 kDa and the accession number is P50053. |