Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11782 |
KRN2 bromide
|
Others | Others |
KRN2 bromide 是有效的、选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂 (IC50= 100 nM)。KRN2 bromide 可用于研究 NFAT5-介导的慢性关节炎。 | |||
T6137 |
KRN-633
KRN633,N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
KRN-633 是一种 VEGFR 抑制剂,能够一种 VEGFR1 (IC50:170 nM)、VEGFR2 (IC50:160 nM)、VEGFR3 (IC50:125 nM)。 | |||
T11781 |
KRN2
|
Others | Others |
KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. | |||
T35450 |
α-GalCer analog 8
α-GalCer analog 8,α-Galactosylceramide analog 8 |
||
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicati... |