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Search Results for " kbp "

Targets Recommended: FKBP

12

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T27715	KBP-7018 KBP 7018
	KBP-7018 is a potent, selective tyrosine kinase inhibitor with effects on three fibrotic kinases c-KIT, RET, and PDGFR (IC50 values are 10nM, 7.6 nM and 25nM respectively).
T70382	KBP-7018 HCl
	KBP-7018 Hydrochloride is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases (c-KIT, PDGFR, and RET).
T80731	Zifanocycline TFA KBP-7072 TFA
	Zifanocycline TFA (KBP-7072) 是一种半合成的氨基糖苷类抗生素，具有口服活性并能抑制细菌核糖体功能。它对广泛的革兰氏阳性菌和阴性菌示出了体外抗菌活性，包括多种耐药病原体。Zifanocycline TFA 适用于急性细菌性皮肤及皮肤结构感染、社区获得性细菌性肺炎和复杂的腹腔感染的研究。
T70381	GSK2793660 free base
	GSK-2793660 is a cathepsin C inhibitor that may be useful in the treatment of cystic fibrosis, noncystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.
T18610	PROTAC FKBP Degrader-3	Others; PROTACs	Others; PROTAC
	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
T11292	FKBP12 PROTAC dTAG-7 dTAG-7	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
T18597	dFKBP-1	Others; PROTACs	Others; PROTAC
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T13694	FKBP12 PROTAC RC32 RC32	Others; PROTACs	Others; PROTAC
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
T79184	FKBP51F67V-selective antagonist Ligand2	FKBP	Apoptosis; Autophagy; Immunology/Inflammation
	FKBP51F67V-selective antagonist Ligand2（示例3-3）是针对杏仁核中由FKBP51 F67V过表达引起的焦虑表型的有效逆转剂。本物质特异性地结合到FKBP51 F67V，与野生型FKBP51及FKBP52无亲和力。
T71840	FKBP12-IN-Q2
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T11291	FKBP12 PROTAC dTAG-13 dTAG-13	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
T74144	Zifanocycline
	Zifanocycline (KBP-7072) 为半合成第三代氨甲基环素类抗生素，通过抑制细菌核糖体功能而发挥作用。它对革兰氏阳性菌和革兰氏阴性菌[包括多重耐药病原体]显示出广泛的体外抗菌活性。适用于口服和注射形式，Zifanocycline 主要用于研究治疗急性细菌性皮肤及其结构感染、社区获得性细菌性肺炎以及复杂腹腔感染。

化合物

Cat.No: T27715

Synonym: KBP 7018

Cat.No: T70382

Zifanocycline TFA

Cat.No: T80731

Synonym: KBP-7072 TFA

GSK2793660 free base

Cat.No: T70381

PROTAC FKBP Degrader-3

Cat.No: T18610

Target: Others, PROTACs

FKBP12 PROTAC dTAG-7

Cat.No: T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T18597

Target: Others, PROTACs

FKBP12 PROTAC RC32

Cat.No: T13694

Synonym: RC32

Target: Others, PROTACs

FKBP51F67V-selective antagonist Ligand2

Cat.No: T79184

Target: FKBP

Cat.No: T71840

FKBP12 PROTAC dTAG-13

Cat.No: T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T74144

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03993	KIAA1279 Protein, Human, Recombinant (His & GST) KBP,KIAA1279,TTC2	Human	Baculovirus Insect Cells
	KIAA1279 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 99.6 kDa and the accession number is Q96EK5.
TMPY-00589	KIAA1279 Protein, Human, Recombinant TTC2,KIAA1279,KBP	Human	Baculovirus Insect Cells
	KIAA1279 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 72 kDa and the accession number is Q96EK5.
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His) FKBP4,HSP-binding immunophilin,immunophilin FKB...	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His) 25 kDa FKBP,FKBP-3,Peptidyl-prolyl cis-tra...	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a...
TMPY-01662	FKBP12 Protein, Mouse, Recombinant (His) FK506 binding protein 1A,Fkbp1,FKBP12,F	Mouse	E. coli
	FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883.
TMPY-00510	FKBP11 Protein, Human, Recombinant (mFc) FKBP19,FK506 binding protein 11, 19 kDa	Human	HEK293 Cells
	FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.
TMPY-00808	FKBP12 Protein, Human, Recombinant (His) FKBP12,FKBP1,FKBP-1A,PKCI2,FK506 ...	Human	E. coli
	FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942.
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST) FKBP-25,PPIase,FKBP25,FK506 binding protei...	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
TMPY-03385	FKBP14 Protein, Human, Recombinant (His) IPBP12,EDSKMH,FK506 binding protein 14, 22 kDa,FKBP...	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehler...
TMPY-03148	FKBP7 Protein, Human, Recombinant (His) FK506 binding protein 7,FKBP23,PPIase	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9Y680-2.
TMPJ-00919	FKBP2 Protein, Human, Recombinant (His) also named 13 kDa FK506-binding protein,FK506-binding protei...	Human	HEK293 Cells
	Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It contains 1 PPIase FKBP-type domain and belongs to the FKBP-type PPIase family, FKBP2 subfamily which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 an...
TMPY-02962	FKBP7 Protein, Human, Recombinant (hFc) FKBP23,PPIase,FK506 binding protein 7	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9Y680-2.
TMPY-01555	PRAC Protein, Human, Recombinant (His & SUMO) PRAC,C17orf92	Human	E. coli
	The PRAC gene is located on chromosome 17 at position 17q21, about 4 kbp downstream from the homeodomain Hoxb-13 gene. The pathogenesis of PCa may be due to the expression levels of PRAC protein, and this protein can serve as a potential biomarker for the management of PCa.

重组蛋白

KIAA1279 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03993

Species: Human

Expression System: Baculovirus Insect Cells

KIAA1279 Protein, Human, Recombinant

Cat.No: TMPY-00589

Species: Human

Expression System: Baculovirus Insect Cells

FKBP4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01076

Species: Human

Expression System: E. coli

FKBP25/FKBP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01068

Species: Human

Expression System: E. coli

FKBP12 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01662

Species: Mouse

Expression System: E. coli

FKBP11 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00510

Species: Human

Expression System: HEK293 Cells

FKBP12 Protein, Human, Recombinant (His)

Cat.No: TMPY-00808

Species: Human

Expression System: E. coli

FKBP25/FKBP3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02259

Species: Human

Expression System: E. coli

FKBP14 Protein, Human, Recombinant (His)

Cat.No: TMPY-03385

Species: Human

Expression System: HEK293 Cells

FKBP7 Protein, Human, Recombinant (His)

Cat.No: TMPY-03148

Species: Human

Expression System: HEK293 Cells

FKBP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00919

Species: Human

Expression System: HEK293 Cells

FKBP7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02962

Species: Human

Expression System: HEK293 Cells

PRAC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPY-01555

Species: Human

Expression System: E. coli

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