Cat. No. | Product Name | Target | Signaling Pathways |
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T4530L |
KN-92
K92,KN-92 free base,K 92 |
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KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93. | |||
T21766 |
ML352
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ML352 是一种突触前胆碱转运体(CHT) 的非竞争性抑制剂,对于表达人 CHT 和小鼠前脑突触体的 HEK293细胞的Ki 值分别为 92 nM 和 166 nM。 | |||
T21857 |
AR-R 17779 hydrochloride
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AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 完全激动剂,对α7和α4β2亚型的Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能(迷走神经)通路减轻炎症。 | |||
T78086 | S1R agonist 1 hydrochloride | Sigma receptor | GPCR/G Protein |
S1R agonist 1 (Compound 6b) hydrochloride,是一种高选择性S1R激动剂,其Ki值针对S1R为0.93 nM而对S2R为92 nM。该化合物能对抗反应性氧种(ROS)和N-甲基-D-天冬氨酸(NMDA)引发的神经毒性,显示出神经保护效果。 | |||
T38161 |
STING Agonist C11
STING Agonist C11 |
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STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro... | |||
T35789 | Palmitic acid-1-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35791 | Palmitic acid-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... |