Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15096 |
Delgocitinib
JTE-052,迪高替尼,Corectim(Delgocitinib) |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Delgocitinib(JTE-052)是一种特异性的JAK(Janus激酶)抑制剂,其对JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 2.8、2.6、13 和 58 nM。Delgocitinib 通过JAK-依赖性细胞因子参与多种炎症和自身免疫性疾病,能有效地遏制多种细胞因子信号传递,同时抑制了因细胞因子而引发的瘙痒。它可广泛用于治疗各种炎症性疾病,包括自身免疫性疾病和超敏反应。 | |||
T69949 | CGP-78608 | ||
CGP-78608 is a glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. | |||
T69950 |
Delgocitinib EtOH
|
||
Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation. |