Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79791 |
Immunosuppressant-1
|
Apoptosis | Apoptosis |
Immunosuppressant-1(Compound 31)抑制抗-CD3/抗-CD28共刺激的T细胞增殖,具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP,从而诱导细胞凋亡(apoptosis)。 | |||
T21493 |
Cyclosporin H
|
Others | Others |
Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂,可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。 | |||
T82756 |
Cedelizumab
RWJ 49004 |
||
Cedelizumab (RWJ 49004)为靶向CD4的IgG4亚型单克隆抗体,呈现免疫抑制特性。 | |||
T37288 |
Remisporine B
|
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Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chrom... | |||
T76836 | Tucotuzumab | ||
Tucotuzumab (Anti-EPCAM Recombinant Antibody) 一种由人上皮细胞粘附分子 (EpCAM) 抗原特异性 IgG1 单克隆抗体组成的蛋白质,与两个 IL-2分子相连。Tucotuzumab 是一种免疫抑制剂和抗肿瘤活性分子。 | |||
T83217 |
Abetimus
LJP 394 free base |
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Abetimus (LJP 394 free base)为一种由四个双链DNA (dsDNA) 寡核苷酸构成的免疫抑制剂,其作用机制为通过交联B细胞表面的抗dsDNA抗体,从而降低体内抗dsDNA抗体水平,具备作为系统性红斑狼疮研究工具的潜力。 | |||
T76719 | Muromonab | ||
Muromonab 是一种靶向 CD3受体的单克隆抗体。Muromonab 可以阻断所有细胞毒性 T 细胞功能。Muromonab 也作为一种免疫抑制剂用于减少急性实体器官移植排斥反应。 | |||
T36986 |
Colletodiol
|
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Colletodiol is a fungal metabolite that has been found inD. grovesiiand has immunosuppressant and antiviral activities.1,2It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg/ml, respectively).1Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.2 1.Fujimoto, H., Nagano, J., Yamaguchi, K., et al.Immunosuppressive components from an ascomycete, Diplogelasinospora grovesiChem. Pharm. Bull.46(3)423-429(1998) 2.Lai, W., Wang... |