Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40419 |
IRES-C11
IRES-C11 |
c-Myc | Cell Cycle/Checkpoint |
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53. | |||
T83714 |
LAP TFA
Lupus Autoantigen Peptide,La Peptide |
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Lupus autoantigen peptide (LAP) 是源自La的一种抗病毒肽,La是系统性红斑狼疮 (SLE) 患者中发现的一种自身抗原,对应于La的11-28氨基酸。它抑制了丙型肝炎病毒 (HCV) 5’-UTR与内部核糖体进入位点 (IRES) 跨作用因子 (ITAFs),包括多嘧啶片段结合蛋白 (PTB) 和多聚(rC)-结合蛋白2 (PCBP2) 之间的相互作用。LAP (60 µM) 在使用Huh7细胞的报告者测定中抑制了HCV IRES介导的翻译,这一效应可以通过重组的PTB和PCBP2来逆转。 |