Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11412 |
IPN60090
GLS1-IN-1 |
Others; transporter | Metabolism; Others |
IPN60090是一种新型、强效、口服生物利用度高的 肾型谷氨酰胺酶(GLS1)特异性抑制剂,对GLS1的IC50值为31 nM。IPN60090 具有潜在的抗癌和免疫刺激/免疫调节活性,可选择性地靶向、结合并抑制人谷氨酰胺酶,可用于研究 GLS1 介导的疾病。 | |||
T39544 |
IPN60090 dihydrochloride
IPN60090 dihydrochloride |
||
IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers. |