Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6180 |
INH6
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
INH6 是一种有效的 Hec1 抑制剂,可选择性地破坏 Hec1/Nek2 相互作用并诱导染色体错位。它抑制HeLa 细胞生长的IC50值为2.4 μM。 | |||
T74910 | ODN 24888 | ||
ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN),对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和NF-κB 激活,抑制IL-6的释放。ODN 24888 参与免疫和炎症应答,可作为疫苗佐剂使用。 | |||
T74907 | ODN 21595 | ||
ODN 21595是一种鸟嘌呤修饰的抑制性寡核苷酸(INH-ODN)。该化合物能够抑制IFN-α和IL-6的释放,同时不具有细胞毒性。它还能降低CD86与HLA-DR的表达,显示出对于研究系统性红斑狼疮(SLE)具有潜力。 | |||
T37880 |
OPC-167832
|
||
OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ... |