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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76873 |
Nidanilimab
CAN04 |
IL Receptor | Immunology/Inflammation |
Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体,其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性,切断 IL1α 和 IL1β 信号通路,并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。 | |||
T82938 |
ATUX-1215
|
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ATUX-1215是一种蛋白磷酸酶 2A (PP2A)的激活剂,能够在BLM治疗的动物模型中降低ERK、p38、JNK和Akt的磷酸化及IL-12p70、GM-CSF与IL1α的分泌,从而有助于减缓肺纤维化的发展。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00920 |
IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)
IL-1A,白介素,IL-1 alpha,Interleukin-1 alpha,<... |
Cynomolgus | HEK293 Cells |
The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases. |