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Search Results for " il1rap "

Targets Recommended: IL Receptor

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T76873	Nidanilimab CAN04	IL Receptor	Immunology/Inflammation
	Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体，其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性，切断 IL1α 和 IL1β 信号通路，并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。
T76772	Nadunolimab
	Nadunolimab 是一种靶向IL1RAP 的人IgG1单克隆抗体。Nadunolimab 阻断 IL-1α 和 IL-1β 信号并触发抗体依赖性细胞毒性。Nadunolimab 可用于癌症的研究。

化合物

Nidanilimab

Cat.No: T76873

Synonym: CAN04

Target: IL Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01029	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His) C3orf13,IL1RAP,IL	Mouse	HEK293 Cells
	Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
TMPK-00654	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (aa 21-362, His) C3orf13,IL-1 RAcP,IL-	Cynomolgus	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (aa 21-362, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 40.49 kDa and the accession number is G7NYP7.
TMPK-00330	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi) C3orf13,IL-1 R3,IL1<...	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is Q9NPH3-1.
TMPK-00331	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-359, His & Avi), Biotinylated C3orf13,IL-1 R3,IL-1...	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-359, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is Q9NPH3-1.
TMPJ-01347	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-356, His) IL1RAP,Interleukin-1 Rec...	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-356, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 50-70 KDa and the accession number is Q9NPH3-2.
TMPJ-01346	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc & His) IL-1RAcP,IL-1R3,IL	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 80-100 KDa and the accession number is Q9NPH3-2.
TMPJ-01315	IL-1RL2 Protein, Mouse, Recombinant (His) Interleukin-1 receptor-like 2,IL1...	Mouse	HEK293 Cells
	Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL-1RL2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis...
TMPJ-01314	IL-1RL2 Protein, Mouse, Recombinant (hFc) IL-36R,IL-36 receptor,IL-1	Mouse	HEK293 Cells
	Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL-1RL2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc ta...
TMPJ-00617	IL-33 Protein, Rhesus macaque, Recombinant (His) Interleukin-33,IL1F11,	Rhesus	E. coli
	Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways...
TMPJ-00909	IL-1RA Protein, Mouse, Recombinant IL-1RN,IRAP,Interleukin-1	Mouse	E. coli
	Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and I...