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Cat. No. | Product Name | Target | Signaling Pathways |
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T14369 |
AZD-0284
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ROR | Metabolism |
AZD-0284 是核受体 (RORγ) 的选择性反向激动剂。它对呼吸道疾病及斑块型寻常型银屑病具有潜在的应用价值。 | |||
T40043 |
RORγt Inverse agonist 10
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RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01219 |
IL-23R Protein, Mouse, Recombinant (hFc)
Il23r,IL-23R,interleukin... |
Mouse | HEK293 Cells |
Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an... | |||
TMPJ-00351 |
IL-23R Protein, Human, Recombinant (aa 24-353, hFc)
IL-23 receptor,IL23R,Interleukin-... |
Human | HEK293 Cells |
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I... | |||
TMPY-05274 |
IL-23R Protein, Human, Recombinant (His)
interleukin 23 receptor |
Human | HEK293 Cells |
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1. | |||
TMPK-00575 |
IL-23R Protein, Canine, Recombinant (His)
IBD17,IL-23 R,IL-23 receptor |
Canine | HEK293 Cells |
IL-23R Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.31 kDa and the accession number is A0A8I3PXL0. | |||
TMPY-00155 |
IL-23R Protein, Rat, Recombinant (His)
interleukin 23 receptor |
Rat | HEK293 Cells |
IL-23R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.8 kDa and the accession number is F1LX96. | |||
TMPK-01094 |
IL-23R Protein, Mouse, Recombinant (His)
IL-23 receptor,Il23r,IBD17,IL... |
Mouse | HEK293 Cells |
IL-23R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.48 kDa and the accession number is Q8K4B4. | |||
TMPY-03281 |
IL-23R Protein, Human, Recombinant (hFc)
interleukin 23 receptor |
Human | HEK293 Cells |
IL-23R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is AAM44229.1. | |||
TMPK-00652 |
IL-23R Protein, Cynomolgus, Recombinant (His)
IL-23 R,IL-23 receptor,IBD17 |
Cynomolgus | HEK293 Cells |
IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5. | |||
TMPY-03245 |
IL-23R Protein, Rat, Recombinant (hFc)
interleukin 23 receptor |
Rat | HEK293 Cells |
IL-23R Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.4 kDa and the accession number is F1LX96. | |||
TMPY-03008 |
IL-23R Protein, Cynomolgus, Rhesus, Recombinant (hFc)
interleukin 23 receptor |
Cynomolgus,Rhesus | HEK293 Cells |
IL-23R Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is F6XR82. | |||
TMPK-00353 |
IL-23R Protein, Human, Recombinant (aa 24-355, His)
IL-23 R,IBD17,IL-23 receptor |
Human | HEK293 Cells |
IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1. | |||
TMPY-04483 |
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas... |
Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |