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Targets Recommended: ROR

2

抑制剂 & 化合物

12

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T14369 AZD-0284

ROR Metabolism
AZD-0284 是核受体 (RORγ) 的选择性反向激动剂。它对呼吸道疾病及斑块型寻常型银屑病具有潜在的应用价值。
T40043 RORγt Inverse agonist 10

RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R.

化合物

AZD-0284
Cat.No: T14369
Synonym:
Target: ROR
RORγt Inverse agonist 10
Cat.No: T40043
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-01219 IL-23R Protein, Mouse, Recombinant (hFc)

Il23r,IL-23R,interleukin...

Mouse HEK293 Cells
Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an...
TMPJ-00351 IL-23R Protein, Human, Recombinant (aa 24-353, hFc)

IL-23 receptor,IL23R,Interleukin-...

Human HEK293 Cells
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I...
TMPY-05274 IL-23R Protein, Human, Recombinant (His)

interleukin 23 receptor

Human HEK293 Cells
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1.
TMPK-00575 IL-23R Protein, Canine, Recombinant (His)

IBD17,IL-23 R,IL-23 receptor

Canine HEK293 Cells
IL-23R Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.31 kDa and the accession number is A0A8I3PXL0.
TMPY-00155 IL-23R Protein, Rat, Recombinant (His)

interleukin 23 receptor

Rat HEK293 Cells
IL-23R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.8 kDa and the accession number is F1LX96.
TMPK-01094 IL-23R Protein, Mouse, Recombinant (His)

IL-23 receptor,Il23r,IBD17,IL...

Mouse HEK293 Cells
IL-23R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.48 kDa and the accession number is Q8K4B4.
TMPY-03281 IL-23R Protein, Human, Recombinant (hFc)

interleukin 23 receptor

Human HEK293 Cells
IL-23R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is AAM44229.1.
TMPK-00652 IL-23R Protein, Cynomolgus, Recombinant (His)

IL-23 R,IL-23 receptor,IBD17

Cynomolgus HEK293 Cells
IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5.
TMPY-03245 IL-23R Protein, Rat, Recombinant (hFc)

interleukin 23 receptor

Rat HEK293 Cells
IL-23R Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.4 kDa and the accession number is F1LX96.
TMPY-03008 IL-23R Protein, Cynomolgus, Rhesus, Recombinant (hFc)

interleukin 23 receptor

Cynomolgus,Rhesus HEK293 Cells
IL-23R Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is F6XR82.
TMPK-00353 IL-23R Protein, Human, Recombinant (aa 24-355, His)

IL-23 R,IBD17,IL-23 receptor

Human HEK293 Cells
IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.
TMPY-04483 IRAK4 Protein, Human, Recombinant (His)

IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...

Human Baculovirus Insect Cells
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...

重组蛋白

IL-23R Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-01219
Species: Mouse
Expression System: HEK293 Cells
IL-23R Protein, Human, Recombinant (aa 24-353, hFc)
Cat.No: TMPJ-00351
Species: Human
Expression System: HEK293 Cells
IL-23R Protein, Human, Recombinant (His)
Cat.No: TMPY-05274
Species: Human
Expression System: HEK293 Cells
IL-23R Protein, Canine, Recombinant (His)
Cat.No: TMPK-00575
Species: Canine
Expression System: HEK293 Cells
IL-23R Protein, Rat, Recombinant (His)
Cat.No: TMPY-00155
Species: Rat
Expression System: HEK293 Cells
IL-23R Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01094
Species: Mouse
Expression System: HEK293 Cells
IL-23R Protein, Human, Recombinant (hFc)
Cat.No: TMPY-03281
Species: Human
Expression System: HEK293 Cells
IL-23R Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00652
Species: Cynomolgus
Expression System: HEK293 Cells
IL-23R Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03245
Species: Rat
Expression System: HEK293 Cells
IL-23R Protein, Cynomolgus, Rhesus, Recombinant (hFc)
Cat.No: TMPY-03008
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
IL-23R Protein, Human, Recombinant (aa 24-355, His)
Cat.No: TMPK-00353
Species: Human
Expression System: HEK293 Cells
IRAK4 Protein, Human, Recombinant (His)
Cat.No: TMPY-04483
Species: Human
Expression System: Baculovirus Insect Cells
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