Cat. No. | Product Name | Target | Signaling Pathways |
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T61385 |
IDO1/TDO-IN-1
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IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1]. | |||
T78795 |
IDO1/TDO-IN-6
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Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO1/TDO-IN-6(compound 11)为IDO1/TDO双重抑制剂,其IC50值分别为2.25 μM和2.89 μM。在抑制IDO1和TDO方面,其Ki值分别为1.9 μM和3.1 μM。IDO1/TDO-IN-6适用于癌症与免疫学领域的研究。 | |||
T60499 |
IDO1/TDO-IN-2
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IDO1/TDO-IN-2 (Compound 1) 是有效的IDO1/TDO 双重抑制剂,IC50s 分别为 0.1 和 0.07 μM,具有癌症研究的潜力。 | |||
T61140 |
IDO1/TDO-IN-3
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IDO1/TDO-IN-3 is a powerful inhibitor targeting IDO1 and TDO enzymes. It displays noteworthy effectiveness against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). Additionally, IDO1/TDO-IN-3 demonstrates considerable in vivo anti-tumor properties while exhibiting no apparent toxicity [1]. | |||
T60318 |
IDO1/TDO-IN-4
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IDO1/TDO-IN-4 显示出对 IDO1 (IC50 = 3.53 μM) 和 TDO (IC50 = 1.15 μM) 的有效抑制作用,并且具有可接受的安全性和药代动力学特性。IDO1/TDO-IN-4 可与 IDO1 形成氢键,与 TDO 产生 π-π 堆积相互作用。 IDO1/TDO-IN-4 可用于抑郁症以及炎症引起的抑郁症的研究。 |