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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14676 |
BMS-688521
|
Integrin | Cytoskeletal Signaling |
BMS-688521 是一种具有口服活性和高效性的 LFA-1/ICAM 相互作用抑制剂,是白细胞功能相关抗原-1 (LFA-1) 的小分子拮抗剂,具有潜在的抗炎活性。 | |||
T21781 |
A-286982
|
Integrin | Cytoskeletal Signaling |
A 286982是高效的LFA-1/ICAM-1相互作用变构抑制剂,在LFA-1/ICAM-1结合和LFA-1介导的细胞粘附实验中,其IC50分别为44和35 nM。 | |||
T2254 |
A-205804
|
Integrin | Cytoskeletal Signaling |
A-205804 是一种选择性口服有效的先导抑制剂,抑制 E-selectin 和 ICAM-1表达,IC50分别为 20 nM 和 25 nM,可用于慢性炎症疾病的研究。 | |||
T12783 |
RWJ 50271
|
Integrin | Cytoskeletal Signaling |
RWJ 50271 是具有口服活性的选择性LFA-1/ICAM-1相互作用抑制剂,抑制 LFA-1/ICAM-1 介导的细胞粘附,在细胞HL60中的IC50值为 5.0 μM。 | |||
T13147 |
ICAM-1-IN-1
|
Integrin | Cytoskeletal Signaling |
ICAM-1-IN-1 是选择性的 ICAM-1和 E-selectin 抑制剂,IC50值分别为5和7 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00324 |
ICAM-1/CD54 Protein, Rhesus macaque, Recombinant (hFc)
Intercellular adhesion molecule 1,ICAM... |
Rhesus | HEK293 Cells |
Intercellular adhesion molecule 1 (ICAM1) is known as CD54. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-... | |||
TMPY-01142 |
ICAM-1/CD54 Protein, Human, Recombinant (His)
CD54,intercellular adhesion molecule 1,BB2,ICAM... |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51 kDa and the accession number is A0A384MEK5. | |||
TMPY-00981 |
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK)
CD54,ICAM-1,intercellular adhesion molecul... |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.2 kDa and the accession number is A0A384MEK5. | |||
TMPK-00497 |
ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)
ICAM-1,CD54,BB2 |
Cynomolgus | HEK293 Cells |
Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... | |||
TMPK-00872 |
ICAM-1/CD54 Protein, Canine, Recombinant (His)
ICAM-1,CD54,BB2 |
Canine | HEK293 Cells |
Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... | |||
TMPY-06778 |
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480, LEVLFQ)
intercellular adhesion molecule 1,P3.58,ICAM |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480, LEVLFQ) is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.31 kDa and the accession number is NP_000192.2. | |||
TMPY-05393 |
ICAM-1/CD54 Protein, Human, Recombinant (hFc)
P3.58,CD54,ICAM-1,BB2,intercellular adhesi... |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 76.2 kDa and the accession number is A0A384MEK5. | |||
TMPY-06777 |
ICAM-1/CD54 Protein, Human, Recombinant (His & Avi), Biotinylated
intercellular adhesion molecule 1,P3.58,ICAM |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 52.77 kDa and the accession number is NP_000192.2. | |||
TMPY-00825 |
ICAM-1/CD54 Protein, Human, Recombinant (His & hFc)
ICAM-1,BB2,CD54,P3.58,intercellular adhesi... |
Human | HEK293 Cells |
ICAM-1/CD54 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 77.4 kDa and the accession number is A0A384MEK5. | |||
TMPH-01560 |
IL-26 Protein, Human, Recombinant (His & Trx)
|
Human | E. coli |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T... | |||
TMPH-01559 |
IL-26 Protein, Human, Recombinant (His)
|
Human | P. pastoris (Yeast) |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula... | |||
TMPJ-00432 |
GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)
GITRL,TNFSF18,Activation-inducible TNF-related liga... |
Cynomolgus | HEK293 Cells |
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation ... |