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4

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1149	HIV-1 Rev (34-50) HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) 是一种具有抗 HIV-1 活性的 17 个氨基酸多肽。 HIV-1 Rev (34-50) 源自 HIV-1 中 Rev 的 Rev 响应元件结合域。
T16548	PKF050-638	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC50=0.04 μM).
T71786	CID-1304264
	CID-1304264 is an HIV-1 Rev pre-integration inhibitor.
T68666	Benfluron Hydrochloride
	Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity.

化合物

HIV-1 Rev (34-50)

Cat.No: TP1149

Synonym: HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)

Target: HIV Protease

Cat.No: T16548

Target: HIV Protease

Cat.No: T71786

Benfluron Hydrochloride

Cat.No: T68666

Cat. No.	Product Name	Target	Signaling Pathways
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	HIV Protease; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.

天然产物

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cat.No: TN5133

Target: HIV Protease, Topoisomerase

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