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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T69966 Roxadustat-d5

Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...
T4651 Vadadustat

N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548

HIF/HIF Prolyl-Hydroxylase; HIF Angiogenesis; Chromatin/Epigenetic; Metabolism
Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,是一种促红细胞生成剂,在动物慢性肾脏疾病模型中,有用于贫血的研究潜力。

化合物

Roxadustat-d5
Cat.No: T69966
Synonym:
Target:
Vadadustat
Cat.No: T4651
Synonym: N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Cat. No. Product Name Species Expression System
TMPH-01280 EGLN1 Protein, Human, Recombinant (His & Myc)

HPH-2,EGLN1,PHD2,SM-...

Human E. coli
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti...

重组蛋白

EGLN1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01280
Species: Human
Expression System: E. coli
TargetMol Loading
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