Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T67767 |
HIF-1 inhibitor-4
HIF-1 inhibitor-4 |
HIF | Angiogenesis; Chromatin/Epigenetic |
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) 是一种 HIF-1 抑制剂 (IC50: 560 nM)。HIF-1 inhibitor-4 减少 HIF-1α 蛋白水平,但不影响 mRNA 水平。 | |||
T9890 |
HIF1-IN-3
Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- |
HIF | Angiogenesis; Chromatin/Epigenetic |
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) 是HIF-1的有效抑制剂(EC50 = 0.9 μM),可用于抗癌的研究。 | |||
T60524 |
HIF-1α-IN-4
|
Others | Others |
HIF-1α-IN-4 是 HIF-1α抑制剂,在 HEK293T 细胞中的IC50值为 24 nM,具有潜在的抗肿瘤作用。 HIF-1α-IN-4 在缺氧条件下下调 VEGF 和 PDK1 mRNA 的表达。 | |||
T70903 |
KRH102053
|
Others | Others |
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells. | |||
T78834 |
HIV-IN-7
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
Axl-IN-16(Compound 4)为Axl抑制剂,能够抑制Axl表达及抑制HIF活性,并诱导金针菇子实体形成。Axl-IN-16可通过分离红血球菌与猴头菇的“子实体液(FL)”得到。 |