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Cat. No. | Product Name | Target | Signaling Pathways |
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T41365 |
12S-HHT
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12S-HHT 在生命科学相关研究中具有广泛的应用。 | |||
T70446 |
Abivertinib HCl
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Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3380 |
Homoharringtonine
Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate |
STAT | JAK/STAT signaling; Stem Cells |
Homoharringtonine (HHT) 属于生物碱类天然产物,可以抑制蛋白质的翻译,具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体,抑制蛋白质翻译的延伸步骤,从而抑制蛋白质合成,具有抗肿瘤活性。 | |||
T2964 |
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols |
Others | Others |
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中,对5-HETE、HHT、thromboxane B2的形成具有抑制作用。 | |||
TN1957 |
Mulberrofuran Q
MulberrofuranQ |
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Mulberrofuran Q是一种有活性的化合物,可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成 ,可保护神经细胞免受缺氧-缺糖(OGD)诱导的氧化应激的影响。 | |||
T4740 |
Elaidic acid
反油酸,trans-Oleic Acid |
Endogenous Metabolite | Metabolism |
Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪,能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中,反油酸抑制 HHT 和 HETE 的形成,同时诱导前列腺素和血栓素的合成。 | |||
TN4586 |
Mulberrofuran A
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COX | Immunology/Inflammation; Neuroscience |
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). |
Cat. No. | Product Name | Species | Expression System |
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TMPY-01168 |
ALK-1 Protein, Human, Recombinant (His)
ALK1,ALK-1,activin A receptor type II-like 1,HHT2,T... |
Human | HEK293 Cells |
ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310. | |||
TMPY-01384 |
Endoglin/CD105 Protein, Human, Recombinant (His)
endoglin,HHT1,END,ORW1 |
Human | HEK293 Cells |
Endoglin/CD105 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.3 kDa and the accession number is A0A024R878. | |||
TMPY-00650 |
ALK-1 Protein, Human, Recombinant (hFc)
SKR3,ORW2,TSR-I,ALK1,activin A receptor type II-like 1,H... |
Human | HEK293 Cells |
ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310. | |||
TMPY-00783 |
Endoglin/CD105 Protein, Human, Recombinant (hFc)
END,HHT1,ORW1,endoglin |
Human | HEK293 Cells |
Endoglin/CD105 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.5 kDa and the accession number is A0A024R878. | |||
TMPK-00359 |
Endoglin/CD105 Protein, Human, Recombinant (His & Avi)
CD105,ORW,ORW1,ENG,END,Endoglin,HHT1 |
Human | HEK293 Cells |
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response... | |||
TMPJ-00304 |
ALK-1 Protein, Mouse, Recombinant (hFc)
TSR-I,Serine/threonine-protein kinase receptor R3,ALK-1,SKR3... |
Mouse | HEK293 Cells |
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1... |