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2

抑制剂 & 化合物

5

天然产物

6

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T41365 12S-HHT

12S-HHT 在生命科学相关研究中具有广泛的应用。
T70446 Abivertinib HCl

Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A...

化合物

12S-HHT
Cat.No: T41365
Synonym:
Target:
Abivertinib HCl
Cat.No: T70446
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T3380 Homoharringtonine

Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate

STAT JAK/STAT signaling; Stem Cells
Homoharringtonine (HHT) 属于生物碱类天然产物,可以抑制蛋白质的翻译,具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体,抑制蛋白质翻译的延伸步骤,从而抑制蛋白质合成,具有抗肿瘤活性。
T2964 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols

Others Others
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中,对5-HETE、HHT、thromboxane B2的形成具有抑制作用。
TN1957 Mulberrofuran Q

MulberrofuranQ

Mulberrofuran Q是一种有活性的化合物,可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成 ,可保护神经细胞免受缺氧-缺糖(OGD)诱导的氧化应激的影响。
T4740 Elaidic acid

反油酸,trans-Oleic Acid

Endogenous Metabolite Metabolism
Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪,能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中,反油酸抑制 HHT 和 HETE 的形成,同时诱导前列腺素和血栓素的合成。
TN4586 Mulberrofuran A

COX Immunology/Inflammation; Neuroscience
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).

天然产物

Homoharringtonine
Cat.No: T3380
Synonym: Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate
Target: STAT
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
Cat.No: T2964
Synonym: 芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols
Target: Others
Mulberrofuran Q
Cat.No: TN1957
Synonym: MulberrofuranQ
Target:
Elaidic acid
Cat.No: T4740
Synonym: 反油酸,trans-Oleic Acid
Target: Endogenous Metabolite
Mulberrofuran A
Cat.No: TN4586
Synonym:
Target: COX
Cat. No. Product Name Species Expression System
TMPY-01168 ALK-1 Protein, Human, Recombinant (His)

ALK1,ALK-1,activin A receptor type II-like 1,HHT2,T...

Human HEK293 Cells
ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
TMPY-01384 Endoglin/CD105 Protein, Human, Recombinant (His)

endoglin,HHT1,END,ORW1

Human HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.3 kDa and the accession number is A0A024R878.
TMPY-00650 ALK-1 Protein, Human, Recombinant (hFc)

SKR3,ORW2,TSR-I,ALK1,activin A receptor type II-like 1,H...

Human HEK293 Cells
ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310.
TMPY-00783 Endoglin/CD105 Protein, Human, Recombinant (hFc)

END,HHT1,ORW1,endoglin

Human HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.5 kDa and the accession number is A0A024R878.
TMPK-00359 Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

CD105,ORW,ORW1,ENG,END,Endoglin,HHT1

Human HEK293 Cells
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response...
TMPJ-00304 ALK-1 Protein, Mouse, Recombinant (hFc)

TSR-I,Serine/threonine-protein kinase receptor R3,ALK-1,SKR3...

Mouse HEK293 Cells
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1...

重组蛋白

ALK-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01168
Species: Human
Expression System: HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (His)
Cat.No: TMPY-01384
Species: Human
Expression System: HEK293 Cells
ALK-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00650
Species: Human
Expression System: HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00783
Species: Human
Expression System: HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00359
Species: Human
Expression System: HEK293 Cells
ALK-1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00304
Species: Mouse
Expression System: HEK293 Cells
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