Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6870 |
L-685458
L-685,458 |
Apoptosis; Gamma-secretase | Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells |
L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂,抑制淀粉样 β-蛋白前体 γ-分泌酶活性,选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解,可研究阿尔茨海默病和癌症。 | |||
T9588 |
JI130
|
Others | Others |
JI130 能够削弱 Hes1 抑制转录的能力。 JI130 治疗显著减少了小鼠胰腺肿瘤异种移植模型中的肿瘤体积。 | |||
T11718 |
JI051
JI-051 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
JI051 具有抗肿瘤作用,能够与癌症相关蛋白伴侣 prohibitin 2 (PHB2) 相互作用,通过抑制 Notch 下游效应基因 Hes1 转录来促使细胞周期停滞,抑制HEK293 细胞和胰腺癌细胞增殖。 | |||
T68980 | MRK003 | ||
MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cel... |