5
1
Cat. No. | Product Name | Target | Signaling Pathways |
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T71837 |
HBX
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HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species. | |||
T21527 |
HBX 41108
HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈 |
DUB; p53 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
HBX 41108 (HBX-41108) 是一种泛素特异性蛋白酶 7 的非竞争性抑制剂,IC50为 424 nM。它诱导 p53 依赖的凋亡,抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。 | |||
T15464 |
HBX 19818
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DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
HBX 19818 是一种特异性泛素特异性蛋白酶 7 (USP7) 抑制剂,IC50值为 28.1 μM。 | |||
T24129 |
HBX28258
HBX 28258,HBX-28258 |
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HBX28258 is a recombinant human USP7 protein inhibitor. In human colon cancer and embryonic kidney cell, it acts by binding the active site through a covalent mechanism and selectively inactivating USP7 protein. | |||
T11669 |
IR415
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HBV | Microbiology/Virology |
IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制,逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN6458 |
Acetylshikonin
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Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity. |