Cat. No. | Product Name | Target | Signaling Pathways |
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T20168 |
Aurothiomalate sodium
金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂,可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂,也是一种抗风湿剂。 | |||
T37222 |
GLS1 Inhibitor
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GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model. 1.Finlay, M.R.V., Anderton, M., Bailey, A., et al.Discovery of a thiadiazole-pyridazine-based allosteric glutaminase 1 inhibitor series that demons... | |||
T75100 | DM-CO-(CH2)5-SMe | ||
DM-CO-(CH2)5-SMe,一种源自抗体活性分子偶联物(ADC)代谢产物的抗癌剂,对H1703、H1975、COLO704及Colo720E细胞展现出细胞毒性。 | |||
T81377 |
PROTAC NSD3 degrader-1
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PROTACs | PROTAC |
PROTACNSD3 degrader-1 (compound 56),是一种定向作用于NSD3蛋白的PROTAC。在NCI-H1703和A549肺癌细胞系中,该化合物能特异性诱导NSD3的降解,其DC50值分别为1.43 μM和0.94 μM。PROTACNSD3 degrader-1能够抑制H3K36的甲基化,触发细胞凋亡以及细胞周期阻滞,同时降低包括CDC25A、ALDH1A1和IGFBP在内的NSD3相关基因的表达水平。 | |||
T72784 |
OTUB1/USP8-IN-1
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DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
OTUB1/USP8-IN-1 是一种高效的 OTUB1/USP8 抑制剂,具有潜在的抗癌活性,对 OTUB1 和 USP8 的 IC50 值分别为 0.17 和 0.28 nM。OTUB1/USP8-IN-1 可用于研究非小细胞肺癌。 |