Cat. No. | Product Name | Target | Signaling Pathways |
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T11435 | GlyT1 Inhibitor 1 | Others | Others |
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor (IC50: 38 nM for rGlyT1) with antipsychotic activity. | |||
T28260 |
Org-25935
Org 25935,SCH-900435,SCH 900435 |
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Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence. | |||
T37700 |
Org 24598 lithium salt
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Org 24598 lithium salt 是一种甘氨酸转运蛋白1 GlyT-1 抑制剂。Org 24598 lithium salt 可以抑制 [3H]CHIBA-3007 与大鼠体内脑膜的特异性结合(Ki=16.9 nM)。 | |||
T37699 |
Org 24598
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Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibi... |