Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6514 |
Glasdegib
PF-04449913 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂,能够结合到人 SMO(181-787氨基酸位点),IC50=4 nM。 | |||
T71455 | Glasdegib hydrochloride | ||
Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. | |||
T71453 |
TriN2755
|
||
TriN2755 is a synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes. |