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Cat. No. Product Name Target Signaling Pathways
T6514 Glasdegib

PF-04449913

Hedgehog/Smoothened; Smo GPCR/G Protein; Stem Cells
Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂,能够结合到人 SMO(181-787氨基酸位点),IC50=4 nM。
T71455 Glasdegib hydrochloride

Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
T71453 TriN2755

TriN2755 is a synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes.

化合物

Glasdegib
Cat.No: T6514
Synonym: PF-04449913
Target: Hedgehog/Smoothened, Smo
Glasdegib hydrochloride
Cat.No: T71455
Synonym:
Target:
TriN2755
Cat.No: T71453
Synonym:
Target:
TargetMol Loading
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