Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24116 |
GSM-1
gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K |
||
GSM-1 is a modulator of γ-Secretase. | |||
T63208 |
Aβ-IN-1
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Aβ-IN-1 是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ-IN-1 在不抑制 CYP3A4 的情况下,在培养细胞中有效降低 Aβ42 水平,IC50值为 0.091 μM。Aβ-IN-1 显示出良好的药代动力学特征。 | |||
T10211 |
Aβ42-IN-1
|
Others | Others |
Aβ42-IN-1,化合物 1v,是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的情况下,在培养细胞中有效降低Aβ42水平,IC50值为 0.091 μM。Aβ42-IN-1 显示出良好的药代动力学特征。 | |||
T10589L |
BPN-15606
|
Others | Others |
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavai |