Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64366 |
GSK3-IN-4
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3-IN-4是一种 GSK-3抑制剂,对 GSK-3α和 GSK-3β的IC50值为 0.101-1 μM。 | |||
T35560 |
SAR502250
|
||
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic... |