Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69830 |
GSK2239633
|
||
GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy. | |||
T11481 |
GSK2239633A
|
CCR | Immunology/Inflammation; Microbiology/Virology |
GSK2239633A 是趋化因子受体 CCR4 的变构拮抗剂,将 [125I]-TARC 与人 CCR4 结合的 pIC50 为 7.96。 |