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Cat. No.	Product Name	Target	Signaling Pathways
T11441	GNE-987	Epigenetic Reader Domain	Chromatin/Epigenetic
	GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50: 0.03
T12798	(S)-GNE-987	Epigenetic Reader Domain	Chromatin/Epigenetic
	(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T12551	PROTAC BRD4 ligand-1	Epigenetic Reader Domain; Ligands for Target Protein for PROTAC	Chromatin/Epigenetic; PROTAC
	PROTAC BRD4 ligand-1 是 PROTAC GNE-987 靶向 BRD4 蛋白的配体，也是一种 BET 的抑制剂。
T18603	PROTAC BRD4 degrader for PAC-1	Others	Others
	PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.